4-Chloro-8-(trifluoromethyl)quinoline → HCID 23331699, 화합물

HRID 224591

반응식

HRID 224591 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]>Cl>[F:13][C:12]([F:15])([F:14])[C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[CH:4][CH:3]=[C:2]2[NH:16][C:17]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]

참가 물질

4

반응물 2

HCID 902624-Chloro-8-(trifluoromethyl)quinolineHCID 2783401Methyl 2-amino-5-fluorobenzoate

생성물 1

HCID 23331699HCID 23331699, 화합물수율 44.8%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 16 g of 4-chloro-8-trifluoromethylquinoline, 11.62 g of methyl 2-amino-5-fluoro-benzoate and 70 ml of 2 N hydrochloric acid solution was heated to reflux and was allowed to stand overnight at room temperature. The mixture was iced and filtered and the product was empasted with a little water and was vacuum filtered. The recovered crystals were dissolved in methanol and triethylamine was added to the resulting solution until the pH was alkaline. The mixture was iced and filtered and the product was dried to obtain 11.2 g of methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate melting at 166° C.

후처리

  1. temperatureto reflux
  2. filtrationfiltered
  3. filtrationfiltered
  4. dissolutionThe recovered crystals were dissolved in methanol
  5. additiontriethylamine was added to the resulting solution until the pH
  6. filtrationfiltered
  7. customthe product was dried

출처 및 근거

ORD 기록
ord-b82c9c6ff6c04d9e9c80a280606d3ff0
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04233305

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