Hydrochloric Acid → HCID 86611028, 화합물

HRID 2245917노트

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HRID 2245917 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@:8]2([O:17][C@H:16]([CH2:18][OH:19])[C@@H:14]([OH:15])[C@H:12]([OH:13])[C@H:10]2[OH:11])[OH:9])=[CH:4][C:3]=1[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]2([C:33]([O:35]C)=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:23][CH:22]=1.Cl>[OH-].[K+].CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@:8]2([O:17][C@H:16]([CH2:18][OH:19])[C@@H:14]([OH:15])[C@H:12]([OH:13])[C@H:10]2[OH:11])[OH:9])=[CH:4][C:3]=1[CH2:20][C:21]1[CH:22]=[CH:23][C:24]([O:27][C:28]2([C:33]([OH:35])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:25][CH:26]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86611027HCID 86611027, 화합물

생성물 1

HCID 86611028HCID 86611028, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 14797Potassium Hydroxide용매

실험 절차

A solution of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-(1-methoxycarbonyl-cyclopent-1-yloxy)-benzyl]-benzene (0.20 g) in aqueous potassium hydroxide solution (4 mol/l, 5 mL) and methanol (5 mL) is stirred at ambient temperature for 4 h. After neutralizing with aqueous hydrochloric acid (1 mol/l), the mixture is concentrated under reduced pressure, diluted with aqueous NaHCO3 solution and extracted with ethyl acetate. The combined organic phases are dried (Na2SO4), the solvent is removed and the residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0→4:1).

후처리

  1. concentrationthe mixture is concentrated under reduced pressure
  2. additiondiluted with aqueous NaHCO3 solution
  3. extractionextracted with ethyl acetate
  4. dry with materialThe combined organic phases are dried (Na2SO4)
  5. customthe solvent is removed
  6. customthe residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0→4:1)

출처 및 근거

ORD 기록
ord-44100a696ad041a68304f0e21641b32b
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07683160B2

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