Hydrogen Bromide → Meloxicam

HRID 224609노트

반응식

HRID 224609 반응식
Br.C[O:3][C:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[S:7](=[O:15])(=[O:14])[N:6]([CH3:16])[C:5]=1[C:17]([NH:19][C:20]1[S:21][C:22]([CH3:25])=[CH:23][N:24]=1)=[O:18]>C(O)(=O)C>[OH:3][C:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[S:7](=[O:15])(=[O:14])[N:6]([CH3:16])[C:5]=1[C:17]([NH:19][C:20]1[S:21][C:22]([CH3:25])=[CH:23][N:24]=1)=[O:18]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 23331598O-Methyl Meloxicam

생성물 1

HCID 54677470Meloxicam

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

0.5 ml of 48% hydrobromic acid and 1 ml of glacial acetic acid were added to 0.2 gm (0.55 millimols) of 4-methoxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-caboxamide-1,1-dioxide. After standing for 24 hours, the reaction mixture was heated for two hours on a water bath and was subsequently evaporated in vacuo to dryness. The residue was dissolved in methylene chloride, and the solution was washed with water. After drying and evaporating of the organic phase, 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide was obtained with a yield of 0.1 gm (52% of theory).

후처리

  1. temperaturethe reaction mixture was heated for two hours on a water bath
  2. customwas subsequently evaporated in vacuo to dryness
  3. dissolutionThe residue was dissolved in methylene chloride
  4. washthe solution was washed with water
  5. customAfter drying
  6. customevaporating of the organic phase

출처 및 근거

ORD 기록
ord-d7329cedddb3408a8e1d2fb81ea7303b
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04233299

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