Thiourea → 4-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

HRID 2247365노트

반응식

HRID 2247365 반응식
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[NH2:15][C:16]([NH2:18])=[S:17]>C(O)C>[CH3:4][C:3]1[N:15]=[C:16]([NH2:18])[S:17][C:2]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 85861734HCID 85861734, 화합물

생성물 1

HCID 183229114-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A stirred solution of 1-Bromo-1-(3-nitro-phenyl)-propan-2-one (98a) (2.4 g, 9.3 mmol) in ethanol (20 ml) at room temperature is treated with thiourea (0.71 g, 9.3 mmol). The reaction mixture is heated to 70° C. for 10 minutes. The resulting precipitate is removed by filtration and dried under vacuum to give the titled compound.

후처리

  1. customThe resulting precipitate is removed by filtration
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-f76bb2a19363427b8e41b71050e3a3cf
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687637B2

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