N-bromobutanimide → 5-Bromo-2,3-dihydro-1-benzofuran

HRID 2247416노트

반응식

HRID 2247416 반응식
COC(/C=C/[C:7]1[CH:12]=[C:11](O)[C:10]2[O:14][CH:15](C3C=CC(O)=C(O)C=3)[CH:16](C(OC)=O)[C:9]=2[CH:8]=1)=O.[Br:29]N1C(=O)CCC1=O>C(#N)C>[Br:29][C:7]1[CH:12]=[CH:11][C:10]2[O:14][CH2:15][CH2:16][C:9]=2[CH:8]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 5857314Dihydrobezofuran

생성물 1

HCID 27761595-Bromo-2,3-dihydro-1-benzofuran수율 331.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Dihydrobenzofuran (9.34 g) was dissolved in 130 ml of acetonitrile, 13.9 g of N-bromosuccinimide was added thereto and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated, then the residue was dissolved in ethyl acetate and successively washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed, to give 15.94 g of the title compound.

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washsuccessively washed with water and brine
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customthe solvent was removed

출처 및 근거

ORD 기록
ord-549d7ac1e7cd483fa564e3b97750a56c
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687664B2

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