C(O)C.[N:4]1([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[C:15](=O)[CH2:14][CH2:13]3)[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1.[Cl-].[OH:21][NH3+:22].C(N(CC)CC)C>C(OCC)(=O)C.O>[N:4]1([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[C:15](=[N:22][OH:21])[CH2:14][CH2:13]3)[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1
An ethanol (5.0 mL) solution of 5-morpholin-4-yl-indan-1-one (2.20 g), hydroxyl ammonium chloride (1.05 g) and the triethylamine (4.22 mL) was refluxed for 3 hours. Water and ethyl acetate were added to the reaction solution, and the organic layer was partitioned. The obtained organic layer was washed with a saturated sodium chloride solution, and 2.28 g of the title compound was obtained by condensing under reduce pressure after drying over anhydrous magnesium sulfate. The physical properties of the compound are as follows.
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