2-Chlorophenol → 4-(2-chlorophenoxy)benzoic Acid

HRID 2247723노트

반응식

HRID 2247723 반응식
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[OH:17].C(=O)([O-])[O-:19].[K+].[K+].CC(=CC)C.P([O-])(O)(O)=O.[K+].Cl[O-].[Na+]>>[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][C:2]1[CH:9]=[CH:8][C:5]([C:6]([OH:19])=[O:7])=[CH:4][CH:3]=1

참가 물질

7

반응물 6

HCID 72452-ChlorophenolHCID 105532-Methyl-2-buteneHCID 11430Potassium CarbonateHCID 680234-FluorobenzaldehydeHCID 516951Monobasic potassium phosphateHCID 23665760Sodium Hypochlorite

생성물 1

HCID 32483334-(2-chlorophenoxy)benzoic Acid수율 84%

실험 절차

The title compound (1.0 g) was synthesized in a yield of 84% as a yellowish white crystalline solid by conducting the similar reaction to that mentioned in Example 10 (10e) using 4-fluorobenzaldehyde (0.60 g, 5.0 mmol), 2-chlorophenol (0.90 g, 7.0 mmol), potassium carbonate (1.7 g, 13 mmol), 2-methyl-2-butene (2.7 ml, 25 mmol), potassium dihydrogenphosphate (1.7 g, 13 mmol) and sodium hypochlorite (1.4 g, 15 mmol).

후처리

  1. customthe similar reaction to

출처 및 근거

ORD 기록
ord-276bb41441a44af7aab6bd696f7b22fb
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687491B2

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