Sodium Hydroxide → HCID 11978047, 화합물

HRID 2247730노트

반응식

HRID 2247730 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:28][N:29]2[CH2:32][CH:31]([C:33]([O:35]C)=[O:34])[CH2:30]2)[S:6][C:7]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[C:15]([F:27])[CH:14]=2)[O:10][N:9]=1)[CH3:2].[OH-].[Na+]>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:28][N:29]2[CH2:32][CH:31]([C:33]([OH:35])=[O:34])[CH2:30]2)[S:6][C:7]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[C:15]([F:27])[CH:14]=2)[O:10][N:9]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 68523928HCID 68523928, 화합물

생성물 1

HCID 11978047HCID 11978047, 화합물수율 83%

실험 절차

The title compound (0.11 g) was synthesized in a yield of 83% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 3 (3e) using methyl 1-[(4-ethyl-5-{5-[3-fluoro-4-(3-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methyl]azetidine-3-carboxylate (0.14 g, 0.27 mmol) that was obtained in Example 20 (20c) and a 1 N aqueous solution of sodium hydroxide (0.81 mL, 0.81 mmol).

후처리

  1. customthe reaction similar to

출처 및 근거

ORD 기록
ord-973af6e8fbec4819a37a6e615bebd57f
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687491B2

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