Water → 3-(4-Amino-3-nitrophenyl)-1-phenyl-2-propen-1-one

HRID 2247863

반응식

HRID 2247863 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[OH-].[Na+].C([NH:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][C:17]=1[N+:24]([O-:26])=[O:25])(=O)C.O>C(O)C>[NH2:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[CH:2][C:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])=[CH:18][C:17]=1[N+:24]([O-:26])=[O:25]

참가 물질

6

반응물 4

HCID 962WaterHCID 7410AcetophenoneHCID 14798Sodium HydroxideHCID 291355N-(4-formyl-2-nitrophenyl)acetamide

생성물 1

HCID 537490733-(4-Amino-3-nitrophenyl)-1-phenyl-2-propen-1-one수율 94.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of acetophenone (7.2 g) and 4N-sodium hydroxide solution (14 ml) in ethanol (50 ml) was added 4-acetylamino-3-nitrobenzaldehyde (10.4 g) at ambient temperature under stirring and the resultant mixture was stirred at same condition for 2 hours. To the reaction mixture was added water and precipitate was collected by filtration. The precipitate was suspended in water (300 ml) and the resultant mixture was adjusted to pH 4.0 with 10% hydrochloric acid. The precipitate was collected by filtration and washed with brine and dried to give 3-(4-amino-3-nitrophenyl)-1-phenyl-2-propen-1-one (12.7 g).

후처리

  1. filtrationwas collected by filtration
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with brine
  4. customdried

출처 및 근거

ORD 기록
ord-02687328fc6f4df0b0f9d98ad9925211
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05037824

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