Sodium Hydroxide → 6,7-Dimethoxy-2,3-quinolinedicarboxylic acid

HRID 2248104노트

반응식

HRID 2248104 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([C:15]([O:17]CC)=[O:16])[C:7]([C:20]([O:22]CC)=[O:21])=[CH:6]2.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([C:15]([OH:17])=[O:16])[C:7]([C:20]([OH:22])=[O:21])=[CH:6]2

참가 물질

3

반응물 2

HCID 14798Sodium Hydroxide2회HCID 133519282,3-Diethyl 6,7-dimethoxy-2,3-quinolinedicarboxylate

생성물 1

HCID 139230016,7-Dimethoxy-2,3-quinolinedicarboxylic acid수율 101%

실험 절차

A suspension of 26.7 g (80 mmol) of 6,7-dimethoxy-2,3-quinolinedicarboxylic acid, diethyl ester, prepared as described by S. B. Kadin and C. H. Lamphere, J. Org. Chem., 49, 4999 (1984), in 10% sodium hydroxide solution (containing 16 g (400 mmol) of sodium hydroxide) was refluxed for 5 hours. After the filtration of the hot solution, 300 ml of water and subsequently 3N hydrochloric acid were added until the pH reached 1.0. The solids were filtered off by suction, washed thoroughly with water, and dried in vacuo to give 22.4 g of the desired product having a melting point of 264°-266° C.

후처리

  1. customprepared
  2. filtrationAfter the filtration of the hot solution, 300 ml of water and subsequently 3N hydrochloric acid
  3. additionwere added until the pH
  4. filtrationThe solids were filtered off by suction
  5. washwashed thoroughly with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-0a74dd49d3034eb28bde941251a4e7cf
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05037983

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