4-(Butylamino)-3-nitrobenzoic acid → 3-Amino-4-(butylamino)benzoic acid

HRID 2248313노트

반응식

HRID 2248313 반응식
[CH2:1]([NH:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][C:7]=1[N+:15]([O-])=O)[CH2:2][CH2:3][CH3:4].[H][H]>[Ni].CO>[NH2:15][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:6]=1[NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[C:10]([OH:12])=[O:11]

참가 물질

5

반응물 2

HCID 28298164-(Butylamino)-3-nitrobenzoic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 115502333-Amino-4-(butylamino)benzoic acid수율 100%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A mixture of 50 parts of 4-(butylamino)-3-nitrobenzoic acid and 240 parts of methanol was hydrogenated in a Parr apparatus at 3.105Pa and at room temperature with 40 parts of Raney Nickel catalyst under nitrogen atmosphere. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over diatomaceous earth and the filtrate was evaporated to dry, yielding 43.7 parts (100%) of 3-amino-4-(butylamino)benzoic acid; mp. 158° C. (int. 8).

후처리

  1. filtrationthe catalyst was filtered off over diatomaceous earth
  2. customthe filtrate was evaporated
  3. customto dry

출처 및 근거

ORD 기록
ord-df2cf473d20a471c8b08cf19d3f52160
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05039677

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