Hydrochloric Acid → 5-Amino-1(3-trifluoromethylphenyl)-3-methylpyrazole hydrochloride

반응식

[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([NH:9][NH2:10])[CH:6]=[CH:7][CH:8]=1.N[C:14]([CH3:18])=[CH:15][C:16]#[N:17].[ClH:19]>>[ClH:19].[NH2:17][C:16]1[N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:11])([F:12])[F:1])[CH:4]=2)[N:10]=[C:14]([CH3:18])[CH:15]=1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 706993-Amino-2-butenenitrile

HCID 98650(3-(Trifluoromethyl)phenyl)hydrazine

생성물 1

HCID 233304955-Amino-1(3-trifluoromethylphenyl)-3-methylpyrazole hydrochloride

실험 절차

3-Trifluoromethylphenyl hydrazine (Tetrahedron, 1960, 69) (25.0 g.) was reacted with 3-amino-2-butene nitrile (12.7 g.) as described in Example XLIII to give 36.1 g. product as HCl salt, mp 222°-226°.

후처리

customto give 36.1 g

출처 및 근거

ORD 기록: ord-dd16ca5be6944d7f8769d2b63133f47e
출처 데이터셋: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04234594

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