Lithium hydroxide, monohydrate → 3-Methyl 5-[3(2-quinolinylmethyloxy)-benzyloxy]benzo(b)thiophene-2-carboxylic acid

HRID 2248905노트

반응식

HRID 2248905 반응식
C[O:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[CH:11][C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH2:23][C:24]4[CH:33]=[CH:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[N:25]=4)[CH:17]=3)=[CH:13][C:7]=2[C:6]=1[CH3:34])=[O:4].O.[OH-].[Li+]>C1COCC1.CO.O>[CH3:34][C:6]1[C:7]2[CH:13]=[C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH2:23][C:24]4[CH:33]=[CH:32][C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[N:25]=4)[CH:17]=3)[CH:11]=[CH:10][C:8]=2[S:9][C:5]=1[C:3]([OH:4])=[O:2]

참가 물질

6

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 54370568Methyl-3-methyl-5-[3-(2quinolinylmethyloxy)benzyloxy]benzo(b)thiophene-2-carboxylate

생성물 1

HCID 149952903-Methyl 5-[3(2-quinolinylmethyloxy)-benzyloxy]benzo(b)thiophene-2-carboxylic acid

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of methyl-3-methyl-5-[3-(2quinolinylmethyloxy)benzyloxy]benzo(b)thiophene-2-carboxylate (355 mg, 0.76 mmol) in THF (10 ml), methanol (10 ml) and water (10 ml) at room temperature is added lithium hydroxide monohydrate (156 mg, 3.71 mmol). The resulting solution is stirred for 16 hours and concentrated. The residue is suspended in water and washed with ether. The aqueous layer is acidified to pH 3. The precipitated solid is filtered, washed with water and methylene chloride and dried to provide 3-methyl 5-[3(2-quinolinylmethyloxy)-benzyloxy]benzo(b)thiophene -2-carboxylic acid.

후처리

  1. concentrationconcentrated
  2. washwashed with ether
  3. filtrationThe precipitated solid is filtered
  4. washwashed with water and methylene chloride
  5. customdried

출처 및 근거

ORD 기록
ord-7cea00d4174348b4b4bc0770e03309c0
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05041453

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