Hydrochloric Acid → HCID 86745006, 화합물

HRID 2249011노트

반응식

HRID 2249011 반응식
[F:1][C:2]1[C:7]([C@@H:8]([OH:10])[CH3:9])=[C:6]([F:11])[C:5]([F:12])=[C:4]([F:13])[C:3]=1[F:14].[CH3:15][S:16](Cl)(=[O:18])=[O:17].C(N(CC)CC)C.Cl>CCOCC>[CH3:15][S:16]([O:10][C@H:8]([C:7]1[C:2]([F:1])=[C:3]([F:14])[C:4]([F:13])=[C:5]([F:12])[C:6]=1[F:11])[CH3:9])(=[O:18])=[O:17]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 6993305S(-)-1-(PENTAFLUOROPHENYL)ETHANOL

생성물 1

HCID 86745006HCID 86745006, 화합물수율 83%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To an ice-cooled solution of 0.21 g (1 mmol) of (S)-(-)-1-(pentafluorophenyl)ethanol and 0.17 g (1.5 mmol) of methanesulfonyl chloride in 2 m(of ether, was added dropwise 0.22 m((1.6 mmol) of triethylamine. After it was stirring for two hours at room temperature, 1N hydrochloric acid was added to the reaction mixture and was extracted with ether. This ether solution was washed with 1N hydrochloric acid and an aqueous solution of 5 wt% potassium carbonate , and the solvent was distilled off under reduced pressure. The subsequent distillation gave 0.24 g (yield: 83%) of (S)-(-)-1-(pentafluorophenyl)ethyl methanesulfonate having the aforementioned physical properties.

후처리

  1. extractionwas extracted with ether
  2. washThis ether solution was washed with 1N hydrochloric acid
  3. distillationan aqueous solution of 5 wt% potassium carbonate , and the solvent was distilled off under reduced pressure
  4. distillationThe subsequent distillation

출처 및 근거

ORD 기록
ord-af6fd32cc21e4a2bb4f90e213a92cc3c
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05041641

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