Ethanolamine → HC Yellow No. 15

HRID 2249131

반응식

HRID 2249131 반응식
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[NH2:14][CH2:15][CH2:16][OH:17].C(Cl)(Cl)Cl>CO>[OH:17][CH2:16][CH2:15][NH:14][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

참가 물질

5

반응물 3

HCID 700EthanolamineHCID 6212ChloroformHCID 279424-Chloro-3-nitrobenzamide

생성물 1

HCID 21909558HC Yellow No. 15

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Add 6.0 g (0.03 moles) 4-chloro-3-nitrobenzamide to 60 ml 2-aminoethanol and stir at ambient temperature. When TLC (silica support; 9:1 CHCl3 :MeOH eluent) shows no starting material, ca. 3 hrs., pour onto ice. Filter, wash (3×15 ml) with cold H2O, and recrystallize from MeOH/IPA. Yield is 4.5 g (66%) of orange crystals.

후처리

  1. customno starting material, ca. 3 hrs
  2. addition, pour onto ice
  3. filtrationFilter
  4. washwash (3×15 ml) with cold H2O
  5. customrecrystallize from MeOH/IPA

출처 및 근거

ORD 기록
ord-677f69249f10496d9c9f6d16bb7bb1ba
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05042988

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