Potassium Bicarbonate → HCID 19825784, 화합물

HRID 2249209노트

반응식

HRID 2249209 반응식
C(O)(=O)C.C(O)(=O)C.[O:9]1[C:22]([CH3:24])([CH3:23])[CH:10]1[CH2:11][C:12]1[C:13]([OH:21])=[CH:14][C:15]([O:19][CH3:20])=[C:16]([CH:18]=1)[OH:17].C(=O)([O-])O.[K+]>CO>[OH:9][C:22]([CH:10]1[CH2:11][C:12]2[CH:18]=[C:16]([OH:17])[C:15]([O:19][CH3:20])=[CH:14][C:13]=2[O:21]1)([CH3:24])[CH3:23]

참가 물질

4

반응물 2

HCID 516893Potassium BicarbonateHCID 86745023HCID 86745023, 화합물

생성물 1

HCID 19825784HCID 19825784, 화합물수율 80.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 5-(2,3-epoxy-3-methylbutyl)-2-methoxyhydroquinone diacetate (1.848 g) in methanol (36 ml) was added potassium hydrogencarbonate (1.50 g) in one portion. The mixture was stirred for 21 hours at ambient temperature and concentrated in vacuo. The residue was dissolved in a mixture of ethyl acetate (30 ml) and saturated sodium chloride solution (30 ml). The separated organic layer was washed with saturated sodium chloride solution, dried, and evaporated to dryness. The oily residue was crystallized from isopropyl ether to yield 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-6-methoxy-5-benzofuranol (964 mg) as a white solid.

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in a mixture of ethyl acetate (30 ml) and saturated sodium chloride solution (30 ml)
  3. washThe separated organic layer was washed with saturated sodium chloride solution
  4. customdried
  5. customevaporated to dryness
  6. customThe oily residue was crystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-0e5d249d524f410ab85b84892ca7cddc
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05043354

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