4-(3-Hydroxypropylamino)-3-nitropyridine → 3-Amino-4-(3-hydroxypropylamino)pyridine

HRID 22495

반응식

HRID 22495 반응식
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[N+:12]([O-])=O>C(O)C.[Ni]>[NH2:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[NH:5][CH2:4][CH2:3][CH2:2][OH:1]

참가 물질

4

반응물 1

HCID 5923304-(3-Hydroxypropylamino)-3-nitropyridine

생성물 1

HCID 190429283-Amino-4-(3-hydroxypropylamino)pyridine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

4-(3-Hydroxypropylamino)-3-nitropyridine (4.12 g, 20.9 mmol) was dissolved in ethanol (130 ml) and Raney nickel (411 mg, 7.0 mmol) added. The stirred mixture was hydrogenated for 3 days. The catalyst was removed by filtration under argon and the solvent removed under reduced pressure to give 3-amino-4-(3-hydroxypropylamino)pyridine as a brown oil which was used directly in the next step.

후처리

  1. customThe catalyst was removed by filtration under argon
  2. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-4c30fde3bc5e4f7d969c58ff09cd5573
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428168

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