Diethyl Ether → 9b-Allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline

HRID 224969

반응식

HRID 224969 반응식
[CH2:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[CH:6]=[CH:5][C:4]=2[NH:3][CH2:2]1.[C:14]1(C([O-])=C([N+]([O-])=O)C=[C:19]([N+]([O-])=O)[CH:18]=1)[N+]([O-])=O.C1([C:44]([OH:45])=C([N+]([O-])=O)C=C([N+]([O-])=O)C=1)[N+]([O-])=O.[OH-].[Li+].[CH3:48]COCC>C(O)C>[CH2:19]([C:9]12[C:8]3[CH:10]=[C:11]([O:45][CH3:44])[CH:12]=[CH:13][C:7]=3[CH2:6][CH:5]=[C:4]1[N:3]([CH3:48])[CH2:2][CH2:1]2)[CH:18]=[CH2:14]

참가 물질

7

반응물 5

HCID 3283Diethyl EtherHCID 3939Lithium HydroxideHCID 6954Picric AcidHCID 4432340Picrate3회HCID 111479652,3-Dihydro-1h-benzo[e]indole

생성물 1

HCID 233307809b-Allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The benz[e]indoline IIa was regenerated from the picrate XIVd (X=picric acid) as follows: A mixture of finely powder picrate (10 mmol), 1 N aqueous lithium hydroxide (50 ml), ethanol (20 ml) and ether (100 ml) in a separatory funnel was shaken until all the picrate had dissolved. The ether phase was washed with water and, after drying, was evaporated to dryness to give the free base IIa quantitatively.

후처리

  1. dissolutionhad dissolved
  2. washThe ether phase was washed with water
  3. customafter drying
  4. customwas evaporated to dryness
  5. customto give the free base IIa quantitatively

출처 및 근거

ORD 기록
ord-2a59832b8cf3466b9a85bdd208afeaee
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04234731

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