Lithium Hydroxide → 5-(2-Methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

HRID 2250442노트

반응식

HRID 2250442 반응식
C([O:3][C:4]([C:6]1[NH:19][C:9]2=[CH:10][N:11]=[C:12]([O:14][CH2:15][CH2:16][O:17][CH3:18])[CH:13]=[C:8]2[CH:7]=1)=[O:5])C.[Li+].[OH-]>C1COCC1.CO>[CH3:18][O:17][CH2:16][CH2:15][O:14][C:12]1[CH:13]=[C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:19][C:9]2=[CH:10][N:11]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 59820057ethyl 5-(2-methoxyethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

생성물 1

HCID 692283985-(2-Methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1 g (3.784 mmol) 5-(2-Methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester (example 10 (iii)) in 50 mL THF and 25 mL MeOH 15.14 mL of a 1M LiOH solution were added. The mixture was stirred for 2 h at room temperature. The organic solvents were removed in vacuo, the solution acidified and concentrated in vacuo. The residue was purified by flash chromatography over silica gel using H2Cl2/MeOH/HOAc/H2O=90/10/1/1 as eluent. The product fractions were combined, concentrated in vacuo and lyophilized.

후처리

  1. customThe organic solvents were removed in vacuo
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by flash chromatography over silica gel
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-34c9cf3d15c8491baf660a184dacdf04
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07317027B2

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