Trifluoroacetic acid → 3-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cycloheptene

HRID 225048노트

반응식

HRID 225048 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[C:7]([CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH3:22])(O)[C:6]=2[CH:23]=1.[BH4-].[Na+].FC(F)(F)C(O)=O>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7]([CH2:17][CH2:18][CH2:19][O:20][CH2:21][CH3:22])[C:6]=2[CH:23]=1

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 4311764Sodium borohydrideHCID 233288763-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cyclohepten-5-ol

생성물 1

HCID 123351493-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cycloheptene

실험 절차

3-Amino-5-(3-ethoxypropyl)-5H-dibenzo[a,d]cyclohepten-5-ol (10 g., 0.032 mole) and sodium borohydride (12.3 g., 0.325 mole) are ground together in a mortar. The mixture is added in portions to 250 ml. of trifluoroacetic acid, cooled in ice, and stirred vigorously under a stream of nitrogen in an efficient fume hood. Upon completion of the addition, the mixture is stirred for 15 minutes and the bulk of the trifluoroacetic acid removed under vacuum.

후처리

  1. additionThe mixture is added in portions to 250 ml
  2. additionUpon completion of the addition
  3. stirringthe mixture is stirred for 15 minutes
  4. customthe bulk of the trifluoroacetic acid removed under vacuum

출처 및 근거

ORD 기록
ord-31acb281c19242dd8919b06beaeef67f
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04235820

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