Hydroxide → 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

HRID 2250560노트

반응식

HRID 2250560 반응식
[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21]C)=[O:20])=[CH:17][CH:16]=1)(=[O:14])=[O:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-]>CO>[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:23][CH:24]=1)(=[O:13])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 961HydroxideHCID 57444531Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate

생성물 1

HCID 574445324-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate (3.38 g) and 85% pottasium hydroxide (1.28 g) in methanol (40 mL) was stirred for 35 minutes. Methanol was evaporated off, and to the mixture was added 1N hydrochloric acid (20 mL). A white crystal was formed, which was collected by filtration and washed with water and diisopropyl ether, and dried under vacuum. 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid was obtained as a white crystal (2.92 g).

후처리

  1. customMethanol was evaporated off
  2. additionto the mixture was added 1N hydrochloric acid (20 mL)
  3. customA white crystal was formed
  4. filtrationwhich was collected by filtration
  5. washwashed with water and diisopropyl ether
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-6589a3b881c64dc1b36b6007a889f3f6
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07317009B2

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