Chlorosuccinimide → 5-Chloro-2-hydroxy-3-methoxybenzoic acid

HRID 2251591

반응식

HRID 2251591 반응식
[OH:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:13]N1C(=O)CCC1=O>C(O)(=O)C>[Cl:13][C:8]1[CH:9]=[C:10]([O:11][CH3:12])[C:2]([OH:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 701403-Methoxysalicylic acid

생성물 1

HCID 6765015-Chloro-2-hydroxy-3-methoxybenzoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

step a) 2-hydroxy-3-methoxy-benzoic acid (13) is chlorinated for example with N-chlorosuccinimide in acetic acid to yield 5-chloro-2-hydroxy-3-methoxy benzoic acid (14); step b) the methoxy group of compound (14) is reacted with hydrobromic acid in acetic acid to yield 5-chloro-2,3-dihydroxybenzoic acid (15);

출처 및 근거

ORD 기록
ord-4587e8ed799b4dcfaf0764edb72fe1d0
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07319101B2

연결된 노트

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