Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

HRID 225249

반응식

HRID 225249 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9](=[O:12])[CH2:10][CH3:11])[CH:6]=[CH:7][CH:8]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH3:20][N:18]([CH3:19])[CH:17]=[C:10]([CH3:11])[C:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=1)=[O:12]

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 137064Propiophenone, 3'-(trifluoromethyl)

생성물 1

HCID 545299423-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

실험 절차

A mixture of 25 g. of m-trifluoromethylpropiophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed overnight and then evaporated to an oil. The oil is dissolved in hexane and the solution is refrigerated giving crystals of the desired product, m.p. 53°-55° C.

후처리

  1. additionA mixture of 25 g
  2. customevaporated to an oil
  3. dissolutionThe oil is dissolved in hexane

출처 및 근거

ORD 기록
ord-5fff47f6d35c4586a4b592f9e37d7b09
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236005

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