Diboron → 8-Methyl-4-(alpha,alpha,alpha-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine

HRID 225260노트

반응식

HRID 225260 반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[N:14]3[CH:15]=[N:16][C:17]([C:18](O)=O)=[C:13]3[N:12]=[CH:11][CH:10]=2)[CH:4]=1.B#B>O1CCCC1>[CH3:18][C:17]1[N:16]=[CH:15][N:14]2[C:9]([C:5]3[CH:4]=[C:3]([C:2]([F:22])([F:1])[F:21])[CH:8]=[CH:7][CH:6]=3)=[CH:10][CH:11]=[N:12][C:13]=12

참가 물질

4

반응물 2

HCID 6328200DiboronHCID 233298734-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid

생성물 1

HCID 233298508-Methyl-4-(alpha,alpha,alpha-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 0.010 mole of 4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid in tetrahydrofuran is added dropwise to a 0.02 molar solution of diborane in tetrahydrofuran chilled in an ice bath. The mixture is allowed to warm to room temperature and stand overnight. The mixture is poured onto ice and extracted with methylene chloride. The methylene chloride extract is washed with water and dried (MgSO4). The solvent is removed under reduced pressure to give the product of the example.

후처리

  1. temperaturechilled in an ice bath
  2. additionThe mixture is poured onto ice
  3. extractionextracted with methylene chloride
  4. extractionThe methylene chloride extract
  5. washis washed with water
  6. dry with materialdried (MgSO4)
  7. customThe solvent is removed under reduced pressure
  8. customto give the product of the example

출처 및 근거

ORD 기록
ord-fbfd2545f514470185fbfa4aae467df2
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04236005

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