Sodium Hydroxide → Sodium 5-(1,1-dioxido-1,2-thiazinan-2-yl)-7-[({4-fluoro-2-[(isopropylamino)carbonyl]benzyl}amino)carbonyl]-1,6-naphthyridin-8-olate

HRID 2252814노트

반응식

HRID 2252814 반응식
[O:1]=[S:2]1(=[O:36])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=2[C:29]([NH:31][CH:32]([CH3:34])[CH3:33])=[O:30])=[O:19])[C:15]([OH:35])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.[OH-].[Na+:38]>CC(C)=O>[O:36]=[S:2]1(=[O:1])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=2[C:29]([NH:31][CH:32]([CH3:34])[CH3:33])=[O:30])=[O:19])[C:15]([O-:35])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.[Na+:38]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 30134005-(1,1-dioxothiazinan-2-yl)-N-[[4-fluoro-2-(isopropylcarbamoyl)phenyl]methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamide

생성물 1

HCID 69178932Sodium 5-(1,1-dioxido-1,2-thiazinan-2-yl)-7-[({4-fluoro-2-[(isopropylamino)carbonyl]benzyl}amino)carbonyl]-1,6-naphthyridin-8-olate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

5-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-{4-fluoro-2-[(isopropylamino)carbonyl]benzyl}-8-hydroxy-1,6-naphthyridine-7-carboxamide (203 mg, 0.39 mmol) was suspended in acetone (2 mL) and sodium hydroxide (0.39 mL, 0.39 mmol, 1N aqueous solution) was added. The flask was gently warmed to make the solution homogeneous and the solution was then filtered through a glass fiber filter to remove any dust. The solution was stirred at room temperature until solids crashed out of solution. The solids were collected by vacuum filtration to give the title compound as a yellow solid.

후처리

  1. temperatureThe flask was gently warmed
  2. filtrationthe solution was then filtered through a glass fiber
  3. filtrationfilter
  4. customto remove any dust
  5. filtrationThe solids were collected by vacuum filtration

출처 및 근거

ORD 기록
ord-2bc9496928ab47eaac43eadf78235904
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07323460B2

반응 노트

불러오는 중…