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[P].[F:2][C:3]([F:20])([F:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][CH:18]=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1.[OH-].[Na+].CN(C)[CH:25]=[O:26]>>[F:20][C:3]([F:19])([F:2])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([CH:25]=[O:26])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1참가 물질
5
실험 절차
Seventy-five milliliters of dried dimethylformamide is cooled in an ice bath and 25 ml. of phosphorus osychloride is added dropwise with swirling. To this ice cold mixture is added 19.5 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine in one portion and the reaction mixture is then heated on a steam bath for 1.5 hours. The mixture is poured onto ice and made basic (pH 10) with 10 N NaOH. The precipitated solid is removed by filtration and recrystallized from methylene chloride-hexane to give the product, m.p. 196°-198° C.
후처리
- additionThe mixture is poured onto ice
- customThe precipitated solid is removed by filtration
- customrecrystallized from methylene chloride-hexane
- customto give the product, m.p. 196°-198° C.
출처 및 근거
- ORD 기록
- ord-efe35094456244b4878fa9c8652b6426
- 출처 데이터셋
- uspto-grants-1980_11
- 특허 번호
- US04236005
연결된 노트
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