Hydrochloric Acid → HCID 11543260, 화합물

반응식

C([N:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH:22]([F:24])[F:23])[CH2:9]1)(OC(C)(C)C)=O.Cl>>[F:24][CH:22]([F:23])[O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][C@H:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 67073247N-Boc-(R)-2-(2-difluoromethoxybenzyl)morpholine

생성물 1

HCID 11543260HCID 11543260, 화합물

실험 절차

Deprotection of intermediate (a), N-Boc-(R)-2-(2-difluoromethoxybenzyl)morpholine using hydrogen chloride (4M, in methanol), afforded the morpholine example 34 as a colorless oil (37 mg, 65%).

출처 및 근거

ORD 기록: ord-5dd8e4544a7e4e8c92d1e06a5a9d4e77
출처 데이터셋: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07323466B2

반응 노트

불러오는 중…