Sodium Hydroxide → N,N-di-isopropyloxamic acid

HRID 2253711노트

반응식

HRID 2253711 반응식
[CH:1]([N:4]([CH:11]([CH3:13])[CH3:12])[C:5](=[O:10])[C:6]([O:8]C)=[O:7])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[CH:11]([N:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:10])[C:6]([OH:8])=[O:7])([CH3:13])[CH3:12]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11769261HCID 11769261, 화합물

생성물 1

HCID 10910050N,N-di-isopropyloxamic acid수율 35.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

550 mg of methyl N,N-di-isopropyloxamate was dissolved in 20 ml of methanol. The resulting solution was stirred under ice-cooling, to which 15 ml of 1N aqueous solution of sodium hydroxide was added dropwise. After completion of the dropwise addition, the resultant mixture was stirred for 1 hour at room temperature. The solvent was distilled off from the resulting reaction solution under reduced pressure. The residue was added with 20 ml of 1N HCl. Insoluble white precipitates were collected by filtration, washed with chilled water and n-hexane, and then dried to obtain 180 mg of the title compound, N,N-di-isopropyloxamic acid as white solids.

후처리

  1. additionwas added dropwise
  2. additionAfter completion of the dropwise addition
  3. distillationThe solvent was distilled off from the resulting reaction solution under reduced pressure
  4. additionThe residue was added with 20 ml of 1N HCl
  5. customInsoluble white precipitates
  6. filtrationwere collected by filtration
  7. washwashed with chilled water and n-hexane
  8. customdried

출처 및 근거

ORD 기록
ord-deffe7e1489a47869fbb0ea41214ed17
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05232947

반응 노트

불러오는 중…