Methyl iodide → HCID 14078470, 화합물

HRID 2254201노트

반응식

HRID 2254201 반응식
[OH:1][C:2]1[C:7]([CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11])=[C:6]([OH:13])[CH:5]=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15].[C:17](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[OH:1][C:2]1[C:7]([CH2:8][CH:9]=[C:10]([CH3:11])[CH3:12])=[C:6]([O:13][CH3:17])[CH:5]=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 109329712',4'-dihydroxy-3'-prenylacetophenone

생성물 1

HCID 14078470HCID 14078470, 화합물수율 99.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Then, 19.00 g of 2',4'-dihydroxy-3'-(3-methyl-2-butenyl)acetophenone was dissolved in 160 ml of acetone, and 14.29 g of anhydrous potassium carbonate and 6.2 ml of methyl iodide were added to the solution and the mixture was stirred at room temperature in a nitrogen current overnight. After the reaction, the solvent was removed by distillation and the obtained residue was extracted with ether, the extract was washed with water, dried with anhydrous sodium sulfate, and filtered. The solvent was removed from the filtrate by distillation to obtain 20.02 g (yield=99.1%) of 2'-hydroxy-4'-methoxy-3'-(3-methyl-2-butenyl)acetophenone in the form of a colorless oil.

후처리

  1. customAfter the reaction
  2. customthe solvent was removed by distillation
  3. extractionthe obtained residue was extracted with ether
  4. washthe extract was washed with water
  5. dry with materialdried with anhydrous sodium sulfate
  6. filtrationfiltered
  7. customThe solvent was removed from the filtrate by distillation

출처 및 근거

ORD 기록
ord-f23f6e6bd59941b8974866ecc2679c6b
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05234951

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