Hydrochloric Acid → HCID 19744875, 화합물

HRID 2254245노트

반응식

HRID 2254245 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([C:11](=[O:22])[CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[C:5]([O:23][CH2:24][C:25]([O:27]C)=[O:26])[CH:4]=1.[OH-].[K+].Cl>CO>[C:25]([CH2:24][O:23][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[C:6]=1[C:11](=[O:22])[CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=1)([OH:27])=[O:26]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19744869HCID 19744869, 화합물

생성물 1

HCID 19744875HCID 19744875, 화합물수율 87.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Then, 6.05 g of 1-(4,6-dimethoxy-2-methoxycarbonylmethoxyphenyl)-3-(4-methoxyphenyl)-1-propanone was dissolved in 50 ml of methanol, and 30 ml of a 5% aqueous solution of potassium hydroxide was added to the solution and the mixture was stirred at room temperature for 30 minutes to effect reaction. After the reaction, the reaction mixture was made acidic by addition of dilute hydrochloric acid, extracted with diethyl ether and filtered, and the solvent was removed from the filtrate by distillation and the obtained residue was recrystallized from a mixed solvent of diethyl ether and n-hexane to obtain 5.0 g (yield=87.4%) of 1-(2-carboxymethoxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-propanone in the form of a colorless prism.

후처리

  1. customreaction
  2. customAfter the reaction
  3. extractionextracted with diethyl ether
  4. filtrationfiltered
  5. customthe solvent was removed from the filtrate by distillation
  6. customthe obtained residue was recrystallized from a mixed solvent of diethyl ether and n-hexane

출처 및 근거

ORD 기록
ord-49474fc552a147d5b14ef1df2a7e3a01
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05234951

반응 노트

불러오는 중…