2,4-Dimethylfuran → 2-[4-(2-Thienyl)butyryl]3,5-dimethylfuran

HRID 2254328

반응식

HRID 2254328 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O.ClC(Cl)C(OC(=O)C(Cl)Cl)=O.[CH3:23][C:24]1[CH:28]=[C:27]([CH3:29])[O:26][CH:25]=1>ClC(Cl)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][CH2:8][C:9]([C:25]1[O:26][C:27]([CH3:29])=[CH:28][C:24]=1[CH3:23])=[O:11]

참가 물질

5

반응물 3

HCID 194622,4-DimethylfuranHCID 77772Acetic acid, 2,2-dichloro-, 1,1'-anhydrideHCID 783864-(2-Thienyl)Butyric Acid

생성물 1

HCID 197452372-[4-(2-Thienyl)butyryl]3,5-dimethylfuran수율 90%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

반응 조건

온도
50 °C

실험 절차

In 50 ml of dichloroethane were dissolved 8.51 g (0.05 mole) of 4-(2-thienyl)butyric acid and 14.39 g (0.06 mole) of dichloroacetic anhydride. To the resulting solution was added 0.065 mole of 3,5-dimethylfuran and 0.71 g of boron trifluoride-diethyl ether complex and the resulting mixture was then stirred at 50° C. for 7 hours. After completion of the reaction, the reaction solution was cooled and washed successively with 5% aqueous sodium carbonate solution and water. The organic layer was concentrated under reduced pressure to obtain 2-[4-(2-thienyl)butyryl]3,5-dimethylfuran.

후처리

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled
  3. washwashed successively with 5% aqueous sodium carbonate solution and water
  4. concentrationThe organic layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b193a9e606e44f6099d3fdb5674a580b
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05235068

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