Dimethylformamide → Fadrozole
반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:17][N:18](C)C=O>O>[C:17]([C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1)#[N:18]참가 물질
4
실험 절차
A mixture of 85 mg of 5-(p-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 74 mg of cuprous cyanide in 1 ml of N,N-dimethylformamide is heated under nitrogen at 120° for 11 h. The reaction mixture is cooled, diluted with 10 ml of water and extracted with ethyl acetate. The organic extracts are dried over sodium sulfate and evaporated. The resulting oil is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.
후처리
- temperatureis heated under nitrogen at 120° for 11 h
- temperatureThe reaction mixture is cooled
- extractionextracted with ethyl acetate
- dry with materialThe organic extracts are dried over sodium sulfate
- customevaporated
- customThe resulting oil is chromatographed on silica gel with ethyl acetate
출처 및 근거
- ORD 기록
- ord-00f7638125924cf68d1eb79ce35a532a
- 출처 데이터셋
- uspto-grants-1995_06
- 특허 번호
- US05428160
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