Dimethylformamide → Fadrozole

HRID 22548

반응식

HRID 22548 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:17][N:18](C)C=O>O>[C:17]([C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:13]3[CH:14]=[N:15][CH:16]=[C:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1)#[N:18]

참가 물질

4

반응물 2

HCID 6228DimethylformamideHCID 140971965-(p-Bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

생성물 1

HCID 59693Fadrozole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 85 mg of 5-(p-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 74 mg of cuprous cyanide in 1 ml of N,N-dimethylformamide is heated under nitrogen at 120° for 11 h. The reaction mixture is cooled, diluted with 10 ml of water and extracted with ethyl acetate. The organic extracts are dried over sodium sulfate and evaporated. The resulting oil is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.

후처리

  1. temperatureis heated under nitrogen at 120° for 11 h
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic extracts are dried over sodium sulfate
  5. customevaporated
  6. customThe resulting oil is chromatographed on silica gel with ethyl acetate

출처 및 근거

ORD 기록
ord-00f7638125924cf68d1eb79ce35a532a
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428160

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