Water → (2 Aminoeth 1-yl) 4-naphth-1-ylpiperidine

HRID 2255444노트

반응식

HRID 2255444 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl.[C:8]1([CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][C:25]#[N:26])[CH2:20][CH2:19]2)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1.O.[OH-].[Na+]>O1CCCC1>[NH2:26][CH2:25][CH2:24][N:21]1[CH2:22][CH2:23][CH:18]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][CH:9]=2)[CH2:19][CH2:20]1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 19784336(4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochlorideHCID 21226445Aluminium lithium hydride

생성물 1

HCID 19096243(2 Aminoeth 1-yl) 4-naphth-1-ylpiperidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.75 g of lithium aluminum hydride are added in fractions under a stream of nitrogen to a solution of 4.4 g of the compound from Example 4 in 150 ml of tetrahydrofuran. After stirring for 1 hour, the mixture is hydrolyzed with 1.75 ml of water, 3.5 ml of a 10% (wt/wt) sodium hydroxide solution and 7 ml of water. Filtration through celite, followed by evaporation of the solvent, yields an oily product which is used as it is in the following stage.

후처리

  1. filtrationFiltration through celite
  2. customfollowed by evaporation of the solvent
  3. customyields an oily product which

출처 및 근거

ORD 기록
ord-cced53e66a3949e394ff8f2f8924ae07
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05240942

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