Chloroform → HCID 14668265, 화합물

HRID 2255514노트

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HRID 2255514 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][CH3:15])[C:4]=1[C:5]([OH:7])=[O:6].C(Cl)(Cl)[Cl:17]>>[Cl:17][C:11]1[C:3]([O:2][CH3:1])=[C:4]([C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=1)[C:5]([OH:7])=[O:6]

참가 물질

3

반응물 2

HCID 6212Chloroform2회HCID 6114002,3,6-Trimethoxybenzoic acid

생성물 1

HCID 14668265HCID 14668265, 화합물수율 95%

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온도
0 °C

실험 절차

2,5,6-trimethoxybenzoic acid 5.0 g (0.024 mol) was suspended in 75 ml of CHCl3 and cooled to 0° C. 1.9 ml (0.024 mol) of SO2Cl2 was added under N2 -atm. The reaction was stirred for 2 hr and allowed to slowly attain room temperature. The reaction mixture was diluted 100 ml CHCl3 and washed with 200 ml H2O. The aqueous layer was washed with 50 ml CHCl3 and the combined organic layer was dried (Na2SO4) and the solvent was evaporated. Gave 5.5 g (95%) of 3-chloro-2,5,6-trimethoxybenzoic acid (oil). Mw: 246.7.

후처리

  1. customallowed to slowly attain room temperature
  2. washwashed with 200 ml H2O
  3. washThe aqueous layer was washed with 50 ml CHCl3
  4. dry with materialthe combined organic layer was dried (Na2SO4)
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-df260541073a4908ad097bee9561f127
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05240957

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