Phenol → Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate

HRID 2255600노트

반응식

C([O-])([O-])=O.[K+].[K+].CC(C)=O.C1(O)C=CC=CC=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH:24]=[C:25]([O:28][CH3:29])[C:26]=1[OH:27])[CH:22]=[O:23].Br[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[CH2:37][C:38]([O:40][CH3:41])=[O:39]>>[Cl:18][C:19]1[CH:20]=[C:21]([CH2:22][OH:23])[CH:24]=[C:25]([O:28][CH3:29])[C:26]=1[O:27][CH:37]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:31]=1)[C:38]([O:40][CH3:41])=[O:39]

참가 물질

반응물 4

HCID 996Phenol

HCID 296223-Chloro-4-hydroxy-5-methoxybenzaldehyde

HCID 8063364Methyl 2-(2-bromophenyl)acetate

HCID 86600397Acetone potassium carbonate

생성물 1

HCID 19385663Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate수율 64%

실험 절차

Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 0.50 g (2.65 mmol) of 3-chloro-4-hydroxy-5-methoxybenzaldehyde was alkylated with 0.668 g (2.92 mmol) of methyl 2-bromophenylacetate to afford 0.570 g (64%) of the title compound.

출처 및 근거

ORD 기록: ord-9a1472b7b0a744e88212cf8e7f15cd46
출처 데이터셋: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05240938

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