Hydrochloric Acid → 5-(2-Methyl-pyridin-4-yl)-2,3-dihydro-1H-isoindole

HRID 225561

반응식

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([CH3:23])[CH:18]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[CH3:23][C:19]1[CH:18]=[C:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH:22]=[CH:21][N:20]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 577532995-(2-Methyl-pyridin-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

생성물 1

HCID 577533135-(2-Methyl-pyridin-4-yl)-2,3-dihydro-1H-isoindole

실험 절차

Prepared in analogy to Example A3(e) from 5-(2-Methyl-pyridin-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and using trifluoacetic acid instead of hydrochloride acid. Brown solid. MS (m/e): 211.0 ([M+H]+, 100%)

출처 및 근거

ORD 기록: ord-935594ec0c7c4ee4aea8f83444d5f9e6
출처 데이터셋: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07557114B2

연결된 노트

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