Hydrochloric Acid → 5-(5-Methyl-thiophen-3-yl)-2,3-dihydro-1H-isoindole
반응식
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH:21]=[C:20]([CH3:22])[S:19][CH:18]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[CH3:22][C:20]1[S:19][CH:18]=[C:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH:21]=1참가 물질
3
실험 절차
Prepared in analogy to Example A3(e) from 5-(5-Methyl-thiophen-3-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and using trifluoacetic acid instead of hydrochloride acid. Light yellow solid. MS (m/e): 216.1 ([M+H]+, 100%)
출처 및 근거
- ORD 기록
- ord-0aa742015e224035958dfe942c811014
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07557114B2
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