Hydrochloric Acid → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 2255705노트

반응식

HRID 2255705 반응식
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2.Cl.C(=O)([O-])[O-].[K+].[K+]>O>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 19100959HCID 19100959, 화합물

생성물 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.01octane-7-carboxylate are heated under reflux overnight with 30 ml of concentrated hydrochloric acid. The mixture ic concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate, extracted five times with 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

후처리

  1. extractionextracted five times with 50 ml of chloroform each time
  2. dry with materialdried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-830de90d22b94c4091e4e4af99ec72f3
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05241076

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