Toluene → HCID 19738525, 화합물

HRID 2255722노트

반응식

HRID 2255722 반응식
[H-].[Na+].C1(C)C=CC=CC=1.[CH3:10][O:11][CH:12]([O:20][CH3:21])[CH2:13][NH:14][C:15](=[O:19])[O:16][CH2:17][CH3:18].Cl[CH2:23][C:24]([CH2:26][F:27])=[CH2:25]>O>[F:27][CH2:26][C:24](=[CH2:23])[CH2:25][N:14]([CH2:13][CH:12]([O:11][CH3:10])[O:20][CH3:21])[C:15](=[O:19])[O:16][CH2:17][CH3:18]

참가 물질

6

반응물 4

HCID 1140TolueneHCID 24758Sodium hydrideHCID 10921057Ethyl 2,2-dimethoxyethylcarbamateHCID 140720532-(Chloromethyl)-3-fluoroprop-1-ene

생성물 1

HCID 19738525HCID 19738525, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

8 g (0.26 mol) of sodium hydride (80% pure) are initially introduced into 200 ml of toluene and 35.8 g (0.2 mol) of ethyl N-(2,2-dimethoxyethyl)-carbamate are added dropwise at 90° C. The mixture is then stirred for one hour at 90° C. and 32.6 g (0.3 mol) of 1-chloro-2-fluoromethylprop-2-ene are then added dropwise. The mixture is stirred overnight at 90° C., salts are dissolved in water, and the aqueous phase is separated off and extracted with toluene. The organic phases are dried over potassium carbonate and concentrated, and the residue is distilled.

후처리

  1. additionare added dropwise at 90° C
  2. stirringThe mixture is stirred overnight at 90° C.
  3. customthe aqueous phase is separated off
  4. extractionextracted with toluene
  5. dry with materialThe organic phases are dried over potassium carbonate
  6. concentrationconcentrated
  7. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-c8d29045752940a28b933bec92462b20
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05241076

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