1-Benzyloxycarbonyl-4-(2-fluoropyrid-3-yl)piperidine → 2-Fluoro-3-(piperidin-4-YL)pyridine
반응식
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[C:18]([F:23])=[N:19][CH:20]=[CH:21][CH:22]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>FC(F)(F)C(O)=O.C(Cl)(Cl)Cl>[F:23][C:18]1[C:17]([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[CH:22][CH:21]=[CH:20][N:19]=1참가 물질
4
실험 절차
A solution of 1-benzyloxycarbonyl-4-(2-fluoropyrid-3-yl)piperidine (0.36 g) in 5 mL of trifluoroacetic acid was heated to reflux for 30 minutes and evaporated. The residue thus obtained was dissolved in chloroform and evaporated. After repeating this process three times, the named product was obtained as an oil (0.64 g); MS: 181; NMR: 1.6-2.1 (m, 4), 3.0-3.4 (m, 5), 7.2-7.5 (m, 2), 7.8-7.9 (m, 4), 8.1 (m, 1), 8.2-8.8 (br, 2).
후처리
- temperatureto reflux for 30 minutes
- customevaporated
- customThe residue thus obtained
- customevaporated
출처 및 근거
- ORD 기록
- ord-a3865e1e22e34791982fe1e286dcdf22
- 출처 데이터셋
- uspto-grants-1997_08
- 특허 번호
- US05654299
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