Ammonia → 6-Amino-2-fluoronicotinamide

HRID 2256174노트

반응식

HRID 2256174 반응식
[F:1][C:2]1[N:10]=[C:9](F)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[NH3:12].O>C(N)=O>[NH2:12][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([F:1])[N:10]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 962WaterHCID 105830482,6-Difluoropyridine-3-carboxamide

생성물 1

HCID 105348946-Amino-2-fluoronicotinamide수율 31%

시약·촉매·용매 1

HCID 713Formamide용매

실험 절차

A solution of 2,6-difluoronicotinamide (4.68 g, 0.029 mmol) in dry formamide (30 mL) is saturated with ammonia and allowed to stand at room temperature for 24 h. Water (50 mL) is added and the resultant precipitate is filtered off and washed well with water, to give 6-amino-2-fluoronicotinamide (1.41 g, 31%) mp 236°-237° C. 1H NMR (DMSO) δ 7.89 (1H, dd, J=10.4, 8.4 Hz), 7.31, 7.16 (1H, 1H, 2 brs,), 6.93 (2H, brs), 6.36 (1H, dd, J=8.4, 2.4 Hz).

후처리

  1. filtrationthe resultant precipitate is filtered off
  2. washwashed well with water

출처 및 근거

ORD 기록
ord-ea483090fd004c038894c25409b88815
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05654307

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