4-(3-Isopropyl-4-methoxy-phenoxy)-3,5-dimethyl-nitrobenzene → 3,5-Dimethyl4-(3'-isopropyl-4'-methoxyphenoxy)-aniline

HRID 2256481노트

반응식

HRID 2256481 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([N+:21]([O-])=O)[CH:5]=[C:6]([CH3:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([CH:17]([CH3:19])[CH3:18])[CH:10]=1>[Pt].C(O)C>[CH3:20][C:6]1[CH:5]=[C:4]([CH:3]=[C:2]([CH3:1])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([CH:17]([CH3:18])[CH3:19])[CH:10]=1)[NH2:21]

참가 물질

4

반응물 1

HCID 103136024-(3-Isopropyl-4-methoxy-phenoxy)-3,5-dimethyl-nitrobenzene

생성물 1

HCID 100167993,5-Dimethyl4-(3'-isopropyl-4'-methoxyphenoxy)-aniline

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 702Ethanol용매

실험 절차

3,5-Dimethyl-4-(3'-isopropyl-4'-methoxyphenoxy)nitrobenzene (480 mg) and 50 mg of 10% platinum on carbon in 100 ml ethanol are reduced on a Parr shaker. Catalyst is removed by filtration through Celite and the filtrate stripped. The residue is taken up in ether and acidified with gaseous hydrogen chloride. The ether solution is chilled, filtered to remove insolubles, and stripped to afford 3,5-dimethyl-4-(3'-isopropyl-4'-methoxyphenoxy)-aniline hiedrochloride, m.p. 95°-100°.

후처리

  1. customCatalyst is removed by filtration through Celite
  2. temperatureThe ether solution is chilled
  3. filtrationfiltered
  4. customto remove insolubles

출처 및 근거

ORD 기록
ord-7c2ab23343aa4745863b87cdacbbe6f9
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05654468

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