3-Bromo-1-propanol → 1-Pyrrolidinepropanol

HRID 225758

반응식

HRID 225758 반응식
Br[CH2:2][CH2:3][CH2:4][OH:5].[NH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1>C1(C)C=CC=CC=1>[N:6]1([CH2:2][CH2:3][CH2:4][OH:5])[CH2:10][CH2:9][CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 123083-Bromo-1-propanolHCID 31268Pyrrolidine

생성물 1

HCID 2093421-Pyrrolidinepropanol

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

3-Bromopropan-1-ol (27.3 mL, 302 mmol) was added to a solution of pyrrolidine (47.2 g, 655 mmol) in toluene (1000 mL) and the mixture was stirred at room temperature for 48 hours. The reaction mixture was then filtered and the filtrate was evaporated under reduced pressure. The residue was distilled and the title product was obtained as a colourless liquid at 100° C./7 mmHg, (23.1 g, 59%).

후처리

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-2ac62587795a42abb14e610714f0697f
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557121B2

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