Ethyl Acetate → HCID 86594851, 화합물

HRID 225774

반응식

HRID 225774 반응식
[C:1]([NH2:11])(=[O:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Br[CH:13]([CH3:21])[C:14](=O)[CH2:15][C:16]([O:18][CH3:19])=[O:17].C(OC(=O)C)C>CN(C)C=O>[CH3:21][C:13]1[O:10][C:1]([CH:2]=[CH:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[N:11][C:14]=1[CH2:15][C:16]([O:18][CH3:19])=[O:17]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 121352-Propenamide, 3-phenyl-HCID 9815681Methyl 4-bromo-3-oxopentanoate

생성물 1

HCID 86594851HCID 86594851, 화합물수율 11.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Cinnamamide (0.5 g) and methyl 4-bromo-3-oxopentanoate (0.71 g) were dissolved in N,N-dimethylformamide (2.5 ml) and the mixture was stirred 100° C. for 15 h. Ethylacetate (50 ml) was added, and the mixture was washed with water (100 ml) and then with saturated brine (100 ml), and dried (Na2SO4). Ethyl acetate was evaporated under reduced pressure and the obtained residue was purified by column chromatography to give the title compound (0.1 g).

후처리

  1. washthe mixture was washed with water (100 ml)
  2. dry with materialwith saturated brine (100 ml), and dried (Na2SO4)
  3. customEthyl acetate was evaporated under reduced pressure
  4. customthe obtained residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-c173fd40267040489bc68ac8304425c8
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557123B2

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