Sodium Hydroxide → 5-Benzylsulfonylamino-1-methoxymethyl-3-uracilylacetic acid

HRID 2257949노트

반응식

HRID 2257949 반응식
[CH2:1]([S:8]([NH:11][C:12]1[C:13](=[O:28])[N:14]([CH2:22][C:23]([O:25]CC)=[O:24])[C:15](=[O:21])[N:16]([CH2:18][O:19][CH3:20])[CH:17]=1)(=[O:10])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO.O>[CH2:1]([S:8]([NH:11][C:12]1[C:13](=[O:28])[N:14]([CH2:22][C:23]([OH:25])=[O:24])[C:15](=[O:21])[N:16]([CH2:18][O:19][CH3:20])[CH:17]=1)(=[O:10])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22943410Ethyl 5-benzylsulfonylamino-1-methoxymethyl-3-uracilylacetate

생성물 1

HCID 229433865-Benzylsulfonylamino-1-methoxymethyl-3-uracilylacetic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a cooled (0° C.) suspension of the compound of Example 43 (10.0 g, 24 mmole) in methanol (50 mL) is added 1.0N NaOH (49 mL) over a period of 10 minutes. After the addition is complete, the solution is allowed to warm to room temperature over a period of 1.5 hours. The solvent is reduced under vacuum, residue diluted with water, and washed with ethyl acetate twice. The aqueous layer is acidified with 2.0N HCl to pH 1, extracted with ethyl acetate three times. The combined organic extracts are washed with water, then brine (twice). The solvent is removed to give the title compound.

후처리

  1. temperatureTo a cooled
  2. additionAfter the addition
  3. washwashed with ethyl acetate twice
  4. extractionextracted with ethyl acetate three times
  5. washThe combined organic extracts are washed with water
  6. customThe solvent is removed

출처 및 근거

ORD 기록
ord-b73adc05637f4a71956bc616f8322243
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05658930

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