1-Dodecanol → L-lactide epsilon-caprolactone

HRID 2258

반응식

HRID 2258 반응식
C(O)CCCCCCCCCCC.[CH3:14][CH2:15][CH2:16][CH2:17][CH:18]([C:21]([O-:23])=[O:22])[CH2:19]C.CCC[CH2:27][CH:28]([C:31]([O-:33])=[O:32])CC.[Sn+2]>>[C:21]1(=[O:23])[O:22][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1.[CH3:27][C@@H:28]1[O:23][C:21](=[O:22])[C@H:18]([CH3:19])[O:33][C:31]1=[O:32]

참가 물질

3

반응물 2

HCID 81931-DodecanolHCID 93182-ethylhexanoic acid tin(II) salt

생성물 1

HCID 131710947L-lactide epsilon-caprolactone

실험 절차

The procedure in Example 1 was substantially repeated, except that 13.6 mL of 1-dodecanol instead of 4.00 mL of glycerol and 0.12 mL (40 μmol) instead of 0.10 mL of stannous octoate solution were used. The copolymer was dried under vacuum (0.1mm Hg) at 110° C. for about 16 hours to remove any unreacted monomer. The copolymer had an inherent viscosity of 0.15 dL/g in HFIP at 25° C. The copolymer was viscous liquid at room temperature. The molar ratio of PC.L/PLA was found to be 51.5/48.5 by proton NMR.

후처리

  1. customThe copolymer was dried under vacuum (0.1mm Hg) at 110° C. for about 16 hours
  2. customto remove any unreacted monomer
  3. customat 25° C
  4. customat room temperature

출처 및 근거

ORD 기록
ord-32f23f9ca43c4245993689b694a4b02b
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728752

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