Phenol → Methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate

HRID 2258457노트

반응식

HRID 2258457 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:8]1([C:14]2([CH3:21])[O:20][CH:15]2[C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[O:7]([C:14]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:21])[CH:15]([OH:20])[C:16]([O:18][CH3:19])=[O:17])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 996PhenolHCID 228011Methyl 3-methyl-3-phenyloxirane-2-carboxylate

생성물 1

HCID 15766824Methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate

실험 절차

28.2 g (0.3 mol) of phenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are heated together for 6 hours at 100° C. After the excess phenol has been distilled off under greatly reduced pressure and the residue has been purified by chromatography over silica gel using a hexane/ethyl acetate mixture, 17.9 g of a slightly yellow oil are obtained.

후처리

  1. distillationAfter the excess phenol has been distilled off under greatly reduced pressure
  2. customthe residue has been purified by chromatography over silica gel using a hexane/ethyl acetate mixture, 17.9 g of a slightly yellow oil
  3. customare obtained

출처 및 근거

ORD 기록
ord-d170f804c292465eab05bfc8ecc73c93
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05661106

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