Urea → 1-Phenyl-3-propylurea

HRID 2258478노트

반응식

HRID 2258478 반응식
C1(N=C=O)C=CC=CC=1.C(N)CC.NC(N)=O.C(CC(O)=O)#N.N([O-])=O.[Na+].N[C:29]1[N:34]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:33](=[O:41])[N:32](CCC)[C:31](=O)[CH:30]=1.[H][H].NC1C(=O)N(CCC)C(=O)N(C2C=CC=CC=2)C=1N>>[CH2:31]([NH:32][C:33]([NH:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:41])[CH2:30][CH3:29]

참가 물질

9

반응물 8

HCID 1176UreaHCID 7672Phenyl isocyanateHCID 7852PropylamineHCID 9740Cyanoacetic acidHCID 158590685,6-Diamino-1-phenyl-3-propylpyrimidine-2,4(1H,3H)-dioneHCID 229220916-Amino-1-phenyl-3-propylpyrimidine-2,4(1H,3H)-dioneHCID 23668193Sodium NitriteHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 36041381-Phenyl-3-propylurea

실험 절차

N-Propyl-N'-phenylurea was prepared preliminarily from phenyl isocyanate and propylamine by the same procedure as in Reference Example 1. The urea compound as the starting material was reacted with cyanoacetic acid to form a uracil ring. Using sodium nitrite a nitroso group was introduced into the 5-position of the uracil ring in the obtained 6-amino-1-phenyl-3-propyluracil and then reduced with hydrogen gas to prepare 5,6-diamino-1-phenyl-3-propyluracil.

후처리

  1. customto form a uracil ring

출처 및 근거

ORD 기록
ord-63a3d71f38ba47f682fe485b3b780e32
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05661153

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