Methyl iodide → 3-Bromothioanisole

HRID 22592

반응식

HRID 22592 반응식
[Br:1][C:2]1[CH:3]=[C:4]([SH:8])[CH:5]=[CH:6][CH:7]=1.[C:9](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:9][S:8][C:4]1[CH:3]=[C:2]([Br:1])[CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 80597m-Bromobenzenethiol

생성물 1

HCID 27356273-Bromothioanisole

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 3-bromothiophenol (10 g) in acetone (250 mL) was added potassium carbonate (14.6 g) and iodomethane (4.28 mL). The heterogenous mixture was refluxed for 4 hrs., cooled to room temperature, filtered, and concentrated under reduced pressure. Ether (200 mL) was added, and the mixture was filtered again and finally evaporated to dryness to yield the title compound.

후처리

  1. temperatureThe heterogenous mixture was refluxed for 4 hrs
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure
  4. additionEther (200 mL) was added
  5. filtrationthe mixture was filtered again
  6. customfinally evaporated to dryness

출처 및 근거

ORD 기록
ord-581984c1318441db9e89fd4f881319b7
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428171

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