Hydrochloric Acid → 2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

HRID 2259260

반응식

HRID 2259260 반응식
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([N:23]=[C:24]=[O:25])[CH:19]=[C:20]([Cl:22])[CH:21]=1.O.Cl>N1C=CC=CC=1>[Cl:15][C:16]1[CH:17]=[C:18]([NH:23][C:24](=[O:25])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:13][CH:14]=2)[CH:19]=[C:20]([Cl:22])[CH:21]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 944603,5-Dichlorophenyl isocyanateHCID 27749582-(4-Aminophenoxy)-2-methylpropanoic acid

생성물 1

HCID 1953472-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirring solution of 4.95 g (0.025 mole) of 2-(4-aminophenoxy)-2-methylpropionic acid in 50 ml dry pyridine, 4.95 g (0.025 mole) of 3,5-dichlorophenyl isocyanate were added. After 1 hour stirring at room temperature, 150 ml water was added and the mixture was acidified with concentrated HCl. The precipitate was filtered, washed several times with cold water and dried. Recrystallization from aqueous acetone gave small plates 1.81 g (94%) MP 182°-184°.

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed several times with cold water
  3. customdried
  4. customRecrystallization from aqueous acetone
  5. customgave small plates 1.81 g (94%) MP 182°-184°

출처 및 근거

ORD 기록
ord-2609906c21db4039b75320cff996be04
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05472981

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